however, it is believed that TARC/CCL17 (thymus and activation-regulated chemokine) levels are higher in DRESS compared to other severe drug reactions and occur in the acute phase of the disease, inducing the eosinophilia.11,32,45 TARC is a potent chemokine that recruits eosinophils and increases cutaneous lymphocyte attraction by targeting CD4+ and CD8+ T cells to the skin, promoting the production of IL-5 and eotaxin.11,32,45 IL-5, in turn, is a crucial cytokine for eosinophil development, activation and survival.19,22 Eosinophil counts and TARC levels are associated with greater disease severity, involvement of multiple organs and systems, as well as the intensity of the immune response triggered by activated T cells in response to exposure to the medication, as well as viral reactivation from the human herpesvirus family, especially HHV6.11,22,45 Other hematological alterations are observed in DRESS
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Situations requiring high-top shoes and leggings were set forth in Navy regulations, which stated: "Leggings shall be worn by enlisted men of the Navy with any form of dress when under arms for parade or ceremony, for infantry or artillery drill, when in a landing party, or on guard detail, or when on duty ashore as patrol or beachmaster's guard, or as mail orderly"
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